Saindhav Koneru  (Venkatesh Daggubati) is a single father with a dark past who is forced to return to the world of crime after his daughter is diagnosed with spinal muscular atrophy and requires an injection worth Rs. 16 crores.

Set in a fictional city, Chandraprastha, the movie is about Saindhav Koneru, a.k.a SaiKo (Venkatesh). He works as a crane operator in the customs department.

Saindhav has a daughter named Gayathri (Baby Sara Palekar), who is taken care of by Manogya (Shraddha Srinath), a cab driver. One day, Gayathri faints in school. Upon taking her to the hospital, the doctors reveal that Gayathri is suffering from Spinal Muscular Atrophy (SMA).

Gayathri needs to be given an injection worth 17 crores. What did Saindhav do next? Did he save his daughter? What is the connection between him and Mitra (Mukesh Rishi), who leads a cartel dealing in drugs and weapons? This is what the movie is about.